RIP2 (RIPK2) (NM_003821) Human Untagged Clone

CAT#: SC319141

RIPK2 (untagged)-Human receptor-interacting serine-threonine kinase 2 (RIPK2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RIPK2
• Synonyms: CARD3; CARDIAK; CCK; GIG30; RICK; RIP2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003821.4 GTCAGCTCTGGTTCGGAGAAGCAGCGGCTGGCGTGGGCCATCCGGGGAATGGGCGCCCTC
  GTGACCTAGTGTTGCGGGGCAAAAAGGGTCTTGCCGGCCTCGCTCGTGCAGGGGCGTATC
  TGGGCGCCTGAGCGCGGCGTGGGAGCCTTGGGAGCCGCCGCAGCAGGGGGCACACCCGGA
  ACCGGCCTGAGCGCCCGGGACCATGAACGGGGAGGCCATCTGCAGCGCCCTGCCCACCAT
  TCCCTACCACAAACTCGCCGACCTGCGCTACCTGAGCCGCGGCGCCTCTGGCACTGTGTC
  GTCCGCCCGCCACGCAGACTGGCGCGTCCAGGTGGCCGTGAAGCACCTGCACATCCACAC
  TCCGCTGCTCGACAGTGAAAGAAAGGATGTCTTAAGAGAAGCTGAAATTTTACACAAAGC
  TAGATTTAGTTACATTCTTCCAATTTTGGGAATTTGCAATGAGCCTGAATTTTTGGGAAT
  AGTTACTGAATACATGCCAAATGGATCATTAAATGAACTCCTACATAGGAAAACTGAATA
  TCCTGATGTTGCTTGGCCATTGAGATTTCGCATCCTGCATGAAATTGCCCTTGGTGTAAA
  TTACCTGCACAATATGACTCCTCCTTTACTTCATCATGACTTGAAGACTCAGAATATCTT
  ATTGGACAATGAATTTCATGTTAAGATTGCAGATTTTGGTTTATCAAAGTGGCGCATGAT
  GTCCCTCTCACAGTCACGAAGTAGCAAATCTGCACCAGAAGGAGGGACAATTATCTATAT
  GCCACCTGAAAACTATGAACCTGGACAAAAATCAAGGGCCAGTATCAAGCACGATATATA
  TAGCTATGCAGTTATCACATGGGAAGTGTTATCCAGAAAACAGCCTTTTGAAGATGTCAC
  CAATCCTTTGCAGATAATGTATAGTGTGTCACAAGGACATCGACCTGTTATTAATGAAGA
  AAGTTTGCCATATGATATACCTCACCGAGCACGTATGATCTCTCTAATAGAAAGTGGATG
  GGCACAAAATCCAGATGAAAGACCATCTTTCTTAAAATGTTTAATAGAACTTGAACCAGT
  TTTGAGAACATTTGAAGAGATAACTTTTCTTGAAGCTGTTATTCAGCTAAAGAAAACAAA
  GTTACAGAGTGTTTCAAGTGCCATTCACCTATGTGACAAGAAGAAAATGGAATTATCTCT
  GAACATACCTGTAAATCATGGTCCACAAGAGGAATCATGTGGATCCTCTCAGCTCCATGA
  AAATAGTGGTTCTCCTGAAACTTCAAGGTCCCTGCCAGCTCCTCAAGACAATGATTTTTT
  ATCTAGAAAAGCTCAAGACTGTTATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAG
  TTGGGATAGCACCATTTCTGGATCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCC
  ATGCTCTTCAGCAATAATAAATCCACTCTCAACTGCAGGAAACTCAGAACGTCTGCAGCC
  TGGTATAGCCCAGCAGTGGATCCAGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGA
  AGCCTGCCTTAACCAGTCGCTAGATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGA
  CTATGAACTTGTTAGTACCAAGCCTACAAGGACCTCAAAAGTCAGACAATTACTAGACAC
  TACTGACATCCAAGGAGAAGAATTTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAA
  ACAAATGGGTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAA
  TTTACTTCAAAATAAAAGCATGTAAGTGACTGTTTTTCAAGAAGAAATGTGTTTCATAAA
  AGGATATTTATAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003821.4 unedited
  GACATTTGTTATACGACTCCTATAGGGCGGCCGGGTAATTCGGCACGAGGGTCAGCTCTG
  GTTCGGAGAAGCAGCGGCTGGCGTGGGCCATCCGGGGAATGGGCGCCCTCGTGACCTAGT
  GTTGCGGGGCAAAAAGGGTCTTGCCGGCCTCGCTCGTGCAGGGGCGTATCTGGGCGCCTG
  AGCGCGGCGTGGGAGCCTTGGGAGCCGCCGCAGCAGGGGGCACACCCGGAACCGGCCTGA
  GCGCCCGGGACCATGAACGGGGAGGCCATCTGCAGCGCCCTGCCCACCATTCCCTACCAC
  AAACTCGCCGACCTGCGCTACCTGAGCCGCGGCGCCTCTGGCACTGTGTCGTCCGCCCGC
  CACGCAGACTGGCGCGTCCAGGTGGCCGTGAAGCACCTGCACATCCACACTCCGCTGCTC
  GACAGTGAAAGAAAGGATGTCTTAAGAGAAGCTGAAATTTTACACAAAGCTAGATTTAGT
  TACATTCTTCCAATTTTGGGAATTTGCAATGAGCCTGAATTTTTGGGAATAGTTACTGAA
  TACATGCCAAATGGATCATTAAATGAACTCCTACATAGGAAAACTGAATATCCTGATGTT
  GCTTGGCCATTGAGATTTCGCATCCTGCATGAAATTGCCCTTGGTGTAAATTACCTGCAC
  AATATGACTCCTCCTTTACTTCATCATGACTTGAAGACTCAGAATATCTTATTGGACAAT
  GAATTTCATGTTAAGATTGCAGATTTTGGTTTATCAAAGTGGCGCATGATGTCCCTCTCA
  CAGTCACGAAGTAGCAAATCTGCACCAGAAGAGGGACAATTATCTATATGCCACCTGAAA
  ACTATGAACCCTGACAAAATCAAGGCCAGTATCAGCACGATATTTTATTAGCTATTGCAG
  TTATCAACATGGGAAAGTGGTTTATCCAGAAAAAAACCAGCCCTTTTT
• Restriction Sites: Please inquire
• ACCN: NM_003821
• ORF Size: 1623 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_003821.4, NP_003812.1
• RefSeq Size: 2521
• RefSeq ORF: 1623
• Locus ID: 8767
• Domains: pkinase, TyrKc, CARD, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Neurotrophin signaling pathway, NOD-like receptor signaling pathway
• Gene Summary: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]