Human Lysyl tRNA synthetase (KARS) activation kit by CRISPRa

CAT#: GA102512

KARS CRISPRa kit - CRISPR gene activation of human lysyl-tRNA synthetase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KARS1
• Locus ID: 3735
• Kit Components:

  GA102512G1, Lysyl tRNA synthetase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102512G2, Lysyl tRNA synthetase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102512G3, Lysyl tRNA synthetase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130089, NM_005548
• Synonyms: CMTRIB; DFNB89; KARS1; KARS2; KRS
• Summary: 'Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'