Diazepam Binding Inhibitor (DBI) Rabbit Polyclonal Antibody

CAT#: TA355569

DBI Antibody - N-terminal region

Product Images

WB Suggested Anti-DBI Antibody Titration: 1.0 ug/ml Positive Control: HT1080 Whole Cell

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  Rabbit Anti-DBI Antibody Catalog Number: TA355569 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec

Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Human
  Homology: Human: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 12kDa
• Gene Name: diazepam binding inhibitor, acyl-CoA binding protein
• Database Link:
  NP_065438
  Entrez Gene 1622 Human
  UniProt ID B8ZWD2
• Background: DBI is diazepam binding inhibitor. The protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. DBI is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.
• Synonyms: ACBD1; ACBP; CCK-RP; endozepine; EP; MGC70414; OTTHUMP00000203629

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: PPAR signaling pathway