LIF (NM_002309) Human Recombinant Protein

CAT#: TP750008

Recombinant protein of human leukemia inhibitory factor (LIF) produced in E. coli.


  View other "LIF" proteins (7)

USD 425.00

In Stock*

Size
    • 20 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region (Ser23-Phe202) of human LIF
Tag Tag Free
Predicted MW 19.8 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing 20 mM phosphate buffer, pH7.4.
Bioactivity Determined by its ability to induce differentiation of M1 cells. ED50 for this effect is typically < 0.04 ng/ml.
Endotoxin < 0.1 EU per 1 µg of the protein by the LAL
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_002300
Locus ID 3976
UniProt ID P15018
Cytogenetics 22q12.2
Refseq Size 3987
Refseq ORF 606
Synonyms CDF; DIA; HILDA; MLPLI
Summary 'The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]'
Protein Families Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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