LOX

LOX or lysyl oxidase is also known as protein-lysine 6-oxidase, a human protein encoded by the LOX gene. The inhibition of LOX can cause osteolathyrism. When LOX is upregulated by tumor cells, it may promote metastasis of the existing tumor that cause it to become malignant and cancerous.

SKU# TP313323 (20 ug)
Name Recombinant protein of human lysyl oxidase (LOX)
Expression Host HEK293 cells
Cited In-vitro and in-vivo functional
Application Assays

Human LOX from HEK293 cells

LOX purified from HEK293 cells

LOX purified from HEK293 cells shows high purity and protein activity. Activity data is cited from Cell Rep 2017.

Control and rLOX protein

An increased number of metastatic cells was found in the lungs of mice injected with OriGene recombinant LOX protein (SKU# TP313323) compared to control mice injected with PBS. Figure cited from Cell Rep 2017

Recombinant LOX

Knocking down of LOX protein caused a reduction in the number of viable cells., which can be rescued by OriGene LOX protein (SKU# TP313323). Figure cited from EMBO Mol Med 2015

Citations for the recombinant LOX protein (TP313323)

  • Cell Rep 2017, PubMed ID 28445728
  • J. Biol. Chem. Nov 2015 ,PubMed ID 26601954
  • Nature 2015 ,PubMed ID 26017313
  • Cells Tissues Organs (Print) 2015 ,PubMed ID 25924936
  • Cancer Res. 2013, PubMed ID 23188504

Other Cancer Research proteins

Full length human recombinant proteins made in human cell lines.

Protein Name SKU
BAFF (TNFSF13B) TP304672
Bcl-2 TP304498
Bcl x (BCL2L1) TP301314
Ephrin B1 (EFNB1) TP301886
Galectin-1 (LGALS1) TP304674
Galectin-2 (LGALS2) TP309552
Galectin-3 (LGALS3) TP308785
Galectin-4 (LGALS4) TP300026
Galectin-7 (LGALS7) TP309569
Galectin-8 (LGALS8) TP320102
Galectin-9 (LGALS9) TP310750
KGF (FGF7) TP324418
Leukemia Inhibitory Factor (LIF) TP310818
MIF TP305106
Oncostatin-M (OSM) TP304277
P53 (TP53) TP300003
PDGF AA (PDGFA) TP314164
Recoverin (RCVRN) TP300428
S100B TP300277
SMAD4 TP301828
TGF Beta1 (TGFB1) TP300973
TNF-alpha (TNF) TP306983
Vimentin (VIM) TP301546
WIF1 TP305256